Progesterone is one of the 2 main hormones, the other being estrogen, produced each month by the ovaries of menstruating women. Progesterone is also produced in smaller amounts by the adrenal glands, as are other hormones. Progesterone is the major female reproductive hormone, especially during the latter 2 weeks of the monthly menstrual cycle, where it is made by a part of the ovary called the corpus luteum. It is normal for the levels of progesterone to rise and fall during the monthly cycle of pre-menopausal women. Progesterone levels also fluctuate during perimenopause.

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