Customized low-dose naltrexone formulations for specific conditions

Low Dose Naltrexone (LDN) refers to Naltrexone given at doses at or less than 4.5mg daily. Typically, Naltrexone, at “standard” doses (25mg or more), is used in the treatment of opiate addiction. However, at these lower doses, LDN has been shown to act as an Immunomodulator (a drug that can help support immune function by modifying, generally in a beneficial way, the immune system’s response to a threat), working on promoting an increase in T-Lymphocyte levels. LDN acts by increasing your body's production of endorphins, resulting in properties of analgesia, anti-inflammatory, and a general sense of well-being. Bioidentical hormone in Boston, Massachusetts, has also expressed interest in LDN as part of a broader approach to managing autoimmune and inflammatory conditions.

LDN can be compounded in various dosage forms, including capsules, oral liquids, or topical creams. LDN capsules are typically compounded with Microcrystalline cellulose as their filler. Still, other fillers can be used to tailor the medication to your specific needs, with fillers such as Lactulose, Ascorbic acid, Loxoral, or Sucrose.

Low Dose Naltrexone (LDN) is acknowledged as being safe and generally well-tolerated by most patients. The side effects most commonly reported are vivid dreams and sleep disturbances. These side effects will typically present very early on after starting the therapy and tend to decrease in occurrence over time.

Common conditions treated with LDN

  • Inflammatory Bowel Disease
  • Multiple Sclerosis
  • Chronic Fatigue Syndrome
  • Hashimoto’s disease*
  • Complex Regional Pain Syndrome (CRPS)
  • Parkinson’s Disease
  • Vitiligo
  • Scleroderma
  • Psoriasis
  • Anxiety and Depression
  • PCOS
  • Nerve Pain

*Extra care should be taken when treating a Hashimoto patient, with closer titration and testing of T3/T4 levels every 4–8 weeks, due to a possible rapid decrease in antibodies during initiation of therapy.

FOR MORE INFORMATION, VISIT THE LDN RESEARCH TRUST AT
https://ldnresearchtrust.org

FREQUENTLY ASKED QUESTIONS

This FAQ section provides answers to common questions about Low Dose Naltrexone and how it may be used as a therapy option in compounded pharmacy settings.
What is the primary use of Low Dose Naltrexone in compounding pharmacies?
Low-dose Naltrexone is compounded to support immune function and manage chronic conditions such as autoimmune and inflammatory diseases.
Can LDN be made without certain fillers or allergens?
Yes, compounded LDN can be prepared using different fillers to accommodate sensitivities, such as avoiding lactose or using hypoallergenic alternatives.
How is LDN typically administered?
LDN can be compounded into oral capsules, oral liquid formulations, or topical creams based on patient preference and therapeutic needs.
Are there any side effects when starting LDN therapy?
Some patients experience vivid dreams or mild sleep disturbances when starting LDN, but these effects are usually temporary.
What kind of conditions might respond to LDN therapy?
Conditions such as multiple sclerosis, Hashimoto’s disease, CRPS, and fibromyalgia are examples where LDN may provide symptom relief.
Is regular monitoring required during LDN therapy?
Yes, for conditions like Hashimoto’s, hormone levels such as T3/T4 should be checked regularly during treatment to track response and adjust dosage.
How long does it take to see the effects of LDN?
While some individuals may notice changes within a few weeks, full benefits often develop over a few months with consistent use.

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