5-HTP Supreme™ is a synergistic formula of 5-hydroxytryptophan (50 mg) and vitamin B6 (10 mg) per serving for supporting overall neurotransmitter metabolism by providing precursors of serotonin.* 5-HTP readily enters the blood–brain barrier; however, conversion into serotonin requires the cofactor vitamin B6, which is included in this formula.* 5-HTP Supreme™ may be used during the day to support a healthy mood and normal appetite, or it may be used at bedtime to support sleep.* This formula can be used in place of 5-HTP Synergy™ when higher amounts of 5-HTP are recommended.* Recommended Use: Take 1 capsule per day or as directed by your health-care practitioner. Warning: Not recommended for use by pregnant or lactating women, or by those taking selective serotonin reuptake inhibitor (SSRI) or monoamine oxidase inhibitors (MAO) medications.