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Low Dose Naltrexone (LDN) refers to Naltrexone given at doses at or less than 4.5mg daily. Typically, Naltrexone, at “standard” doses (25mg or more), is used in the treatment of opiate addiction. However, at these lower doses, LDN has shown to act as an Immunomodulator (a drug that can help support immune function by modifying, generally in a beneficial way, the immune system’s response to a threat) working on promoting an increase in T-Lymphocyte levels. LDN acts by increasing your bodies production of endorphins resulting in properties of analgesia, anti-inflammatory and general sense of well-being.

LDN can be compounded in various dosages forms including capsules, oral-liquids or topical creams. LDN capsules are typically compounded with Microcrystalline cellulose as its filler but other fillers can be used to tailor the medication to your specific needs with fillers such as Lactulose, Ascorbic acid, Loxoral or Sucrose.

Low Dose Naltrexone (LDN) is acknowledged as being safe and generally well-tolerated by most patients. The side effects most commonly reported are vivid dreams and sleep disturbances. These side effects will typically present very early on after starting the therapy and tend to decrease in occurrence over time.

Common conditions treated with LDN

  • Inflammatory Bowel Disease
  • Multiple Sclerosis
  • Chronic Fatigue Syndrome
  • Hashimoto’s disease*
  • Hashimoto’s disease*
  • Complex Regional Pain Syndrome (CRPS)
  • Parkinson’s Disease
  • Vitiligo
  • Scleroderma
  • Psoriasis
  • Anxiety and Depression
  • PCOS
  • Nerve Pain

*Extra care should be taken when treating a Hashimoto’s patient with closer titration and testing of T3/T4 levels every 4-8 weeks due to a possible rapid decrease in antibodies during initiation of therapy.

FOR MORE INFORMATION, VISIT THE LDN RESEARCH TRUST AT https://ldnresearchtrust.org

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